(R)-tert-butyl (1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbaMate

China [CN]

IUPAC Name: tert-butyl N-[(2R)-1-(4-phenylphenyl)-3-hydroxypropan-2-yl]carbamate

Basic Properties:  A white to off-white solid powder, soluble in polar organic solvents such as DMSO, tetrahydrofuran, and dichloromethane, and sparingly soluble in water; melting point approximately 102-104℃, predicted boiling point 522.1±50.0℃, density 1.10±0.1 g/cm³.

Structural Characteristics: This compound is a chiral carbamate containing a biphenyl structure, a tert-butoxycarbonyl (Boc)-protected amino group, and a hydroxyl group. It also possesses a chiral center, the configuration of which is crucial for ensuring the correct chiral structure of sacubitril valsartan during subsequent synthesis.

Core Use:

It is an important chiral intermediate in the synthesis of sacubitril valsartan, and a key structural unit in constructing the sacubitril portion of the sacubitril valsartan molecule. The chiral purity of this intermediate directly affects the efficacy and safety of the final drug.