(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid

China [CN]

Core Application

It is a key chiral intermediate in the synthesis of sacubitril/valsartan, forming the core structural unit of the sacubitril portion of the sacubitril/valsartan molecule. Sacubitril/valsartan, as an ARNI class drug, is used to treat chronic heart failure and essential hypertension. The chiral purity of this intermediate directly affects the efficacy and safety of the final drug.