(R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid

China [CN]

IUPAC Name: (2E,4R)-5-(4-phenylphenyl)-4-[(2-methylpropan-2-yl)oxycarbonylamino]-2-methylpent-2-enoic acid

Basic Physical Properties:  Appears as a white to off-white solid powder, soluble in polar organic solvents such as DMSO and dimethylformamide, and sparingly soluble in water; detailed physical parameters such as melting point and boiling point are not yet available in unified, publicly available authoritative data.

Structural Characteristics: This compound is a chiral olefinic carboxylic acid containing a biphenyl structure, a tert-butoxycarbonyl-protected amino group, a chiral center, and an unsaturated double bond. These structures are key reaction sites in the subsequent synthesis of sacubitril valsartan.

Core Use:

It is an important intermediate in the synthesis of sacubitril valsartan, the world's first angiotensin receptor-neprilysin inhibitor (ARNI), primarily used to treat chronic heart failure with reduced ejection fraction, and also used to treat essential hypertension. This intermediate is a key material for constructing the sacubitril portion of the sacubitril valsartan structure.