8-Bromo-3-methyl-xanthine

China [CN]

Chemical Properties:

Appearance: White to off-white crystalline powder

Melting point: >300℃

Solubility: Soluble in DMSO and dilute alkaline solutions, slightly soluble in water and ethanol

It is a xanthine derivative, and the bromine atom in the molecule is an active reaction site, capable of undergoing nucleophilic substitution reactions, which can be used to introduce different substituent groups for structural modification.

Uses:

It is an important pharmaceutical intermediate, mainly used in the synthesis of various purine-based drugs. For example, it can be used to synthesize BU4509, a key intermediate for linagliptin, and can also be used to prepare other anti-diabetic and anti-asthma related drugs.

In organic synthesis, it can also be used as a key building block for constructing purine ring structures.