8-Bromo-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione

China [CN]

8-Bromo-7-but-2-ynyl-3-methyl-1-(4-mCore Application

Its primary use is as a synthetic intermediate for linagliptin. Linagliptin, a commonly used DPP-4 inhibitor in clinical practice, works by inhibiting dipeptidyl peptidase-4, thereby prolonging the action of endogenous incretins and consequently stabilizing and lowering blood glucose levels in patients with type 2 diabetes. This compound, as the core structure of linagliptin, is the essential scaffold for constructing the complete chemical structure of linagliptin and is an indispensable key intermediate in the synthesis of this drug.ethyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione