2-(chloromethyl)-4-methylquinazoline

China [CN]

Core Uses

Its primary use is as a synthetic intermediate for linagliptin, a DPP-4 inhibitor commonly used in the clinical treatment of type 2 diabetes. Additionally, it can be used as a reference standard for the 2-chloromethyl impurity related to linagliptin, for quality control and impurity monitoring during the drug's production and research and development processes, ensuring drug purity.

Safety and Transportation Information

Hazardous Properties:  According to GHS classification, it belongs to Skin Corrosion/Irritation Category 1C and Serious Eye Damage/Eye Irritation Category 1.  Under combustion or high-temperature conditions, it may decompose to produce toxic gases such as carbon monoxide, nitrogen oxides, and hydrogen chloride. Its European hazard code is Xn, dangerous goods transport code is 3261, and packaging group is III.

Protection and First Aid:  Handle in a well-ventilated area, wearing impermeable protective clothing, gloves, safety glasses, and a dust mask. If skin or eye contact occurs, immediately rinse with plenty of water and seek medical attention; if inhaled or ingested, do not induce vomiting and seek medical attention immediately.

Spill Handling: Wear protective equipment such as a P3 filter respirator, collect the spilled powder from the upwind side and seal it in a container, dispose of it according to local regulations, and prevent the spilled material from entering sewers.