6-Chloro-3-methyluracil

China [CN]

​Chemical Properties:

Appearance: White to off-white crystalline powder

Melting point: 274-276℃

Solubility: Soluble in DMSO and dimethylformamide, slightly soluble in ethanol, sparingly soluble in water

It is a derivative of uracil and possesses the basic chemical properties of uracil compounds. Under alkaline conditions, the chlorine atom can undergo nucleophilic substitution reactions, serving as an active site for structural modification.

Uses:

It is an important pharmaceutical intermediate, mainly used in the synthesis of antiviral and antitumor drugs. For example, it can be used to prepare nucleoside analog drugs against HIV, and can also be used as a starting material for the synthesis of some drugs targeting the pyrimidine ring.