Pemetrexed disodium intermediate

China [CN]

4-(2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoic acid

This intermediate is a key aromatic ring intermediate in the synthesis of pemetrexed disodium, determining the core structural framework of the target drug. The core differences in various synthesis processes are reflected in the preparation of this intermediate. For example, some processes use p-bromobenzoic acid as the starting material, and through multiple reaction steps, the pyrimidine ring and ethyl chain are constructed to obtain this compound. Subsequently, it is condensed with a glutamic acid derivative to gradually form the complete structure of pemetrexed disodium. Furthermore, improving the synthesis process of this intermediate (such as using a "one-pot reaction" to simplify operations, changing reaction solvents, etc.) can significantly improve the overall synthesis yield.