Scopine-2,2-dithienyl glycolate

China [CN]

Chemical Properties:

Appearance: White to off-white solid.

Melting point: 138-140℃.

Boiling point: 542.3±50.0℃ (predicted).

Density: 1.48±0.1 g/cm³ (predicted).

Solubility: Slightly soluble in chloroform, slightly soluble in methanol when heated.

Acidity constant (pKa): 10.32±0.29 (predicted).

Uses: Primarily used in the synthesis of tiotropium bromide; it is an important pharmaceutical intermediate in the preparation of tiotropium bromide. 2,2-Dithienylglycolic acid scopolamine ester can be obtained by transesterification of scopolamine with methyl 2,2-di(2-thienyl)acetate, and then anhydrous tiotropium bromide can be obtained through a quaternization reaction with methyl bromide.