(5-Amino-1,3,4-thiadiazol-2-yl)methanol

China [CN]

(5-Amino-1,3,4-thiadiazol-2-yl)metPhysical Properties (referencing similar derivatives):

Appearance: Typically a white to off-white crystalline powder.

Solubility: Due to the presence of hydroxymethyl and amino groups, its water solubility is superior to most thiadiazole derivatives. It is also soluble in polar organic solvents such as methanol, ethanol, and dimethylformamide (DMF), and slightly soluble in weakly polar solvents such as ethyl acetate and dichloromethane.

Melting point: Approximately 175–180℃. Stable under dry conditions at room temperature; dehydration condensation or deamination reactions may occur at high temperatures (>200℃).  Storage requires airtight sealing in a cool, dry place, avoiding contact with strong acids and strong oxidizing agents.

Main Uses: As a polyfunctional heterocyclic pharmaceutical intermediate, it is widely used in drug molecule design and synthesis:

Antibacterial drugs: The 1,3,4-thiadiazole ring is the core scaffold for antibacterial activity. The hydroxymethyl group can introduce antibacterial enhancing groups through etherification and esterification reactions, and the amino group can react with acyl chlorides and sulfonyl chlorides to form amide and sulfonamide derivatives, enhancing the drug's inhibitory activity against bacteria.

Antiviral drugs: Used in the synthesis of inhibitors targeting influenza and herpes viruses. The hydroxyl group of the hydroxymethyl group can act as a hydrogen bond donor, increasing the binding affinity of the drug to viral target proteins.

Cardiovascular drugs: Its derivatives can act on platelet aggregation targets, used in the development of new antithrombotic drugs, reducing the risk of bleeding side effects.anol