2-AMINO-5-BROMO-[1,3,4]THIADIAZOLE

China [CN]

Physical Properties (referencing similar derivatives):

Appearance: Typically a white to pale yellow crystalline powder.

Solubility: Soluble in polar organic solvents such as methanol, ethanol, and dimethyl sulfoxide (DMSO), with low solubility in water; the amino group can form salts with strong acids, significantly increasing water solubility after salt formation.

Melting point: Approximately 230–235℃. Stable under normal temperature and dry conditions, but deamination or debromination side reactions may occur at high temperatures (>250℃); the bromine atom is prone to photochemical substitution, so it should be stored in a cool, dry place, protected from light and sealed, and kept away from strong oxidizing agents and strong bases.

Main Uses: As a highly active heterocyclic pharmaceutical intermediate, it is widely used in drug research and development:

Antibacterial drug synthesis: The 1,3,4-thiadiazole ring is the core active scaffold of many antibacterial agents. The amino and bromine atoms can be further modified into amide, sulfonamide, or aryl groups to enhance the drug's inhibitory effect on bacterial cell wall synthesis.

Antitumor drug development: Its derivatives can act on DNA replication targets in tumor cells, and the cytotoxicity and targeting of the molecule can be optimized by introducing different substituents.

Antihypertensive drugs: Used in the synthesis of angiotensin receptor antagonists, the structure of the thiadiazole ring can enhance the binding affinity of the drug to the receptor.