2-BROMO-4,5,6,7-TETRAHYDROTHIENO[3,2-C]PYRIDINE

China [CN]

Physical Properties (referencing similar fused-ring derivatives):

Appearance: Typically a pale yellow to light brown crystalline powder or oily liquid.

Solubility: Soluble in organic solvents such as dichloromethane, chloroform, ethyl acetate, and tetrahydrofuran; has low solubility in water; forms salts with strong acids, and the water solubility increases significantly after salt formation.

Stability: Stable under normal temperature and dry conditions; may undergo ring-opening or debromination reactions when heated (>180°C); the bromine atom is prone to photolysis, so it should be stored in a cool, dry place, protected from light and air, and away from strong reducing agents and strong bases.

Main Uses: As an important pharmaceutical intermediate, it is widely used in drug research and development, with core applications including:

Central Nervous System Drugs: Used in the synthesis of antidepressant and antipsychotic drugs; the tetrahydrothiophenopyridine core is the core scaffold of many neurotransmitter receptor modulators.

Anti-inflammatory and Analgesic Drugs: By modifying the bromine atom site to introduce active groups, compounds with COX-2 selective inhibitory activity can be developed.

Antithrombotic Drugs: Its derivatives can act on platelet aggregation targets, used to optimize the efficacy and safety of anticoagulant drugs.