5-AMINO-1,3,4-THIADIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER

China [CN]

Physical Properties (referencing similar derivatives):

Appearance: Typically a white to off-white crystalline powder.

Solubility: Soluble in polar organic solvents such as methanol, ethanol, and dimethylformamide (DMF), with low solubility in water; the amino and ester groups can form intermolecular hydrogen bonds, resulting in strong crystallinity.

Melting point: Approximately 170–175℃. Stable under dry conditions at room temperature, but may undergo side reactions such as de-esterification and deamination at high temperatures (>200℃); storage requires protection from light, airtight sealing, and storage in a cool, dry place, avoiding contact with strong acids and strong oxidizing agents.

Main Uses: As a high-value heterocyclic pharmaceutical intermediate, it is widely used in drug research and development:

Antibacterial drug synthesis: The 1,3,4-thiadiazole ring is the core active scaffold of many antibacterial agents. The amino and ester groups can be further modified into amide, sulfonamide, and other groups to enhance the targeted inhibitory effect of the drug on bacteria.

Antihypertensive/antidiabetic drug development: Its derivatives can act on angiotensin receptors or insulin-sensitive targets, used in the development of new cardiovascular or diabetes treatment drugs.

Antitumor drug lead compounds: By coupling with aromatic rings, heterocyclic rings, and other groups, the cell penetration and tumor cell selectivity of the molecule can be optimized.