5-CHLOROTHIOPHENE-2-CARBOXYLIC ACID

China [CN]

Physical Properties (refer to similar derivatives):

Appearance: Typically a white to off-white crystalline powder.

Solubility: Soluble in polar organic solvents such as methanol, ethanol, and acetone; readily soluble in alkaline aqueous solutions (e.g., sodium carbonate solution); low solubility in water.

Melting point: Approximately 154–158℃.  It is stable under heat, but decarboxylation can occur at high temperatures, producing chlorothiophene; it should be stored in a sealed, dry container, avoiding contact with strong alkaline substances.

Main Uses: As an important organic synthesis intermediate, it is widely used in the fields of medicine, pesticides, and materials:

Pharmaceutical research: Used in the synthesis of antibacterial, antiviral, and antitumor drugs containing a thiophene ring. The carboxyl group can be modified through amidation and esterification reactions to introduce different functional groups, and the chlorine atom can undergo nucleophilic substitution reactions to optimize drug activity.

Pesticide synthesis: Used in the preparation of thiophene-based herbicides and fungicides. The thiophene ring structure can enhance the selectivity of the compound towards target organisms.

Materials science: Used as a monomer in the synthesis of functional polymers, for the preparation of ion exchange resins and optoelectronic materials.