2'-Hydroxy-3-phenylpropiophenone

China [CN]

Physical Properties (referencing similar derivatives)

Appearance: Typically a white to pale yellow crystalline powder.

It exhibits polar characteristics due to the phenolic hydroxyl group, and is soluble in organic solvents such as methanol, ethanol, acetone, and ethyl acetate, but has low solubility in water.

Melting point is approximately 80–84℃, and it has a high boiling point, requiring distillation under reduced pressure; due to the easy oxidation of the phenolic hydroxyl group, it should be stored in a dark, sealed container, protected from air.

Main Uses: As an important organic synthesis intermediate, both the phenolic hydroxyl group and the ketone carbonyl group in its structure are active reaction sites, mainly used in:

Synthesis of drug molecules: For example, as a lead compound for certain anti-inflammatory and antidepressant drugs. The phenolic hydroxyl group can be modified by etherification and esterification reactions to introduce different functional groups, and the ketone carbonyl group can undergo reduction and addition reactions for structural modification.

Preparation of functional materials: Used in the synthesis of optically active polymers or liquid crystal materials. The hydrogen bonding of the phenolic hydroxyl group can regulate the physicochemical properties of the material.