ETHYL THIAZOLE-4-CARBOXYLATE

China [CN]

Physical Properties: Typically a grayish-white to yellow crystalline solid, with a melting point of 42-44℃, a density of approximately 1.2 g/cm³, a boiling point of 235.7℃ (760 mmHg), and a flash point of 96.4℃. It is soluble in organic solvents such as chloroform, dichloromethane, diethyl ether, and ethyl acetate. Storage conditions: 2-8℃, sealed, and dry.

Synthesis Method: Generally synthesized from thiazole-4-carboxylic acid and ethanol in dichloromethane solvent, with the addition of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC·HCl) and 4-dimethylaminopyridine (DMAP).  The reaction is followed by purification of the target compound using column chromatography.

Uses: Ethyl thiazole-4-carboxylate is an important pharmaceutical intermediate and can be used to synthesize various biologically active compounds, such as antibacterial, anti-inflammatory, and antiviral drugs.

Safety Information: The hazard classification code for this substance is R36/37/38, indicating that it is irritating to the eyes, respiratory tract, and skin. The safety statement is S26, meaning that in case of contact with eyes, rinse immediately with plenty of water and seek medical advice.