(S)-(+)-3-Hydroxytetrahydrofuran

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(S)-(+)-3-Hydroxytetrahydrofuran
Posting date : Nov 21, 2025
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Free Member Scince Jun 27, 2025
FOB Price
detailed discussion
Min. Order Quantity
1
Supply Abillity
hundreds of kgs
Port
Shanghai Port
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Package
Convenient package
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Lena
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Place of Origin
China [CN]
Brand Name
JINLAN
Model Number
+86 15242851296
HS-CODE
-
Package & Delivery Lead Time
Package
Convenient package
Detailed Description

The synthesis of the anti-AIDS drug amperavir requires two important intermediates, one of which is (S)-(+) -3-hydroxytetrahydrofuran. It can be synthesized by methods such as asymmetric borohydride or hydrosilylation of dihydrofuran, asymmetric hydrogenation reduction - intramolecular etherification of 4-chloro-3-carbonyl butyrate, and enzymatic resolution of 3-hydroxytetrahydrofuran racemes. However, in most cases, the optical purity of the product is insufficient.


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