Argatroban Monohydrate(141396-28-3)
China [CN] Argatroban is a synthetic anticoagulant drug and also a reversible competitive thrombin inhibitor. It has a strong selective inhibitory effect on thrombin and inhibits platelet aggregation caused by thrombin. The inhibitory effect on fibrinase is relatively weak. In vitro, it inhibits the formation of thrombi in various thrombosis models. It has been confirmed in the experimental model that this drug is significantly more effective than heparin in preventing coronary thrombosis and can competitively inhibit platelet activation and aggregation induced by thrombin. Unlike heparin, argatroban does not cause thrombocytopenia and does not further prolong the bleeding time after the addition of aspirin. Preliminary research has confirmed that this drug, when used in combination with aspirin, is an effective combination for preventing coronary artery thrombosis. Argatroban is effective for unstable angina pectoris.
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