N-(Benzyl-6-(4-phenylbutoxy)-hexane-1-amine hydrochloride

China [CN]

Source: This is the starting material in the drug master file for the selective long-acting β-adrenergic receptor agonist salmeterol. It can be prepared by reacting 4-phenylbutanol with 1,6-dibromohexane to produce intermediate 1, which is then reacted with benzylamine in the presence of dimethyl sulfoxide and triethylamine.

Uses: Primarily used as an organic synthesis intermediate and a pharmaceutical intermediate.