Ethyl 2-amino-4-thiazoleacetate

China [CN]

1. Appearance and Properties

At room temperature and pressure, it is a white to pale yellow crystalline powder. High-purity products appear as white needle-shaped crystals. Prolonged exposure to air or light may lead to a slight brownish discoloration due to amino oxidation. It has no noticeable irritating odor and is stable in solid form.

2. Melting Point and Solubility

Melting point: Typical range is 130–134°C (the pure product has a narrow melting range of approximately 132–133°C; impurities can lower the melting point and extend the melting range). Purity can be quickly assessed by melting point determination. Solubility:

Readily soluble in polar organic solvents such as methanol, ethanol, ethyl acetate, dichloromethane, and N,N-dimethylformamide (DMF). Its solubility in ethanol at room temperature is approximately 8–12 g/100 mL.

Slightly soluble in ether and toluene, it is poorly soluble in water (solubility <0.3 g/100 mL) and non-polar solvents such as n-hexane.

The ester group hydrolyzes to a carboxylate salt in alkaline conditions (such as Na₂CO₃ or NaOH solutions), significantly increasing its water solubility and facilitating post-processing in aqueous phases.