Tropic acid

China [CN]

Basic Information

CAS Number: 552-63-6.

Molecular Formula: C₉H₁₀O₃.

Molecular Weight: 166.17.

Chemical Name: 3-Hydroxy-2-phenylpropionic acid.

SMILES: OC(=O)C(CO)c1ccccc1.

Physical and Chemical Properties

Appearance: Typically a white crystalline powder.

Melting Point: 116-118°C.

Solubility: Soluble in dimethyl sulfoxide (DMSO), with a solubility of 250 mg/ml (requiring ultrasound assistance).

Uses

Tropic acid can be used as a substrate for the esterification of carboxylic acids and alcohols, such as in a dry Dowex H⁺/NaI catalytic system.

It is one of the raw materials for the synthesis of cyclopentapeptide depsipeptide acid.

It can also be used to synthesize isocoumarin derivatives via a multicomponent photoreaction with tetracyanobenzene (TCNB). Tropical acid is an intermediate in the synthesis of drugs such as tropicamide and anisodamine.