2-(2-Aminothiazol-4-yl) acetic acid hydrochloride

China [CN]

Physical and Chemical Properties

Appearance and State

Usually a white to off-white crystalline powder. Depending on the purity (e.g., 98%/99%) or the synthesis process, the color may be slightly yellowish. In solid form, it is relatively stable and hygroscopic (this should be distinguished from the free acid: the free acid is hygroscopic, while the hydrochloride salt has significantly reduced hygroscopicity due to its salt structure).

Solubility

Readily soluble in polar solvents such as methanol, ethanol, and water (the aqueous solution is weakly acidic due to the dissociation of the hydrochloride salt into H⁺).

Poorly soluble in non-polar solvents such as petroleum ether, n-hexane, and toluene. Purification can be achieved by solvent selection (e.g., recrystallization).

Melting Point

The typical melting point range is 185-190°C (decomposition point, due to condensation of carboxyl and amino groups at elevated temperatures). The actual melting point depends on the purity (impurities can lower the melting point or extend the melting range). Stability

Storage at room temperature and pressure (sealed and protected from light) is stable for 6-12 months.

Avoid contact with strong oxidizing agents (such as potassium permanganate, hydrogen peroxide) or strong reducing agents (such as sodium borohydride), as these may cause thiazole ring opening or amino oxidation.

Decomposes easily at high temperatures (>200°C) or in strong alkaline conditions (such as concentrated NaOH). Use in a neutral or slightly acidic environment.