5-AMINO-1,3,4-THIADIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER

China [CN]

Physical and Chemical Properties

1. Physical Properties

Appearance and State: White to off-white crystalline powder at room temperature (depending on purity, the color may have a slight yellowish or off-white tint, with higher purity products having a lighter color).

Melting Point: Literature reports a melting point range of 172-176°C (stable when heated; avoid prolonged heating above the melting point to prevent decomposition).

Solubility: Slightly soluble in water, soluble in polar organic solvents such as methanol, ethanol, ethyl acetate, and dichloromethane, with good solubility in DMF (N,N-dimethylformamide) and DMSO (dimethyl sulfoxide), and insoluble in non-polar solvents such as petroleum ether and n-hexane. (Solubility can be used for product purification, such as in the selection of recrystallization solvents).

Stability: Stable for over 12 months when stored at room temperature in a dry, dark, and sealed environment. Exposure to moisture or strong acids/bases may cause protonation or acylation of the amino group, and hydrolysis of the ester group. Strictly controlled storage is required.