2-Amino-5-methyl-1,3,4-thiadiazole

China [CN]

Application Areas

1. Pharmaceuticals (Core Applications)

As a key intermediate, it is used in the synthesis of a variety of biologically active drug molecules, such as:

Antibacterial drugs: It can be combined with quinolones and β-lactams to enhance the inhibitory activity of drugs against Gram-negative bacteria (such as Escherichia coli);

Anti-inflammatory drugs: Thiadiazole compounds obtained through derivatization can inhibit cyclooxygenase (COX-2) activity and are used in the development of non-steroidal anti-inflammatory drugs;

Antidiabetic drugs: Some derivatives can act on the insulin signaling pathway, improving insulin sensitivity, and serve as lead compounds for type 2 diabetes drugs. 2. Pesticide Applications

Used for the synthesis of highly effective, low-toxic agricultural chemicals, primarily including:

Herbicides: Derivatized products can inhibit amino acid synthesis (such as acetolactate synthase) in weeds, showing specific efficacy against grass weeds and being highly safe for crops;

Fungicides: By forming complexes with metal ions, they can control fungal diseases of crops (such as wheat powdery mildew and rice sheath blight), providing both protective and therapeutic effects.

3. Materials and Other Applications

Functional Materials: They can be used as monomers to undergo polycondensation reactions with formaldehyde and phenols to prepare polymer resins containing thiadiazole rings for use in coatings and adhesives, enhancing their corrosion resistance and high-temperature resistance.

Analytical Chemistry: Because amino groups can coordinate with metal ions, they can be used as colorants or extractants for the detection and separation of heavy metal ions (such as Pb²⁺ and Cd²⁺) in environmental water samples. V. Safety and Storage

1. Safety Information

Hazard Classification: Non-hazardous chemical (in compliance with GB 12268), no explosive, flammable, or acutely toxic risk.

Health Effects: Prolonged or high-volume contact may irritate the skin and mucous membranes (e.g., eyes and respiratory tract). It is recommended to wear a dust mask, latex gloves, and goggles when handling. In case of accidental ingestion, induce vomiting immediately and seek medical attention. Toxicity data are not available (LD₅₀ > 2000 mg/kg, oral rat).

Environmental Effects: Low toxicity to aquatic organisms. Avoid indiscriminate discharge. Discarded product should be treated as "organic solid waste" (incineration or landfill by a professional organization). 2. Storage Requirements

Storage Conditions: Store sealed in a dry, cool, well-ventilated warehouse at a temperature ≤ 30°C and a relative humidity ≤ 75%.

Isolation Requirements: Store away from strong acids, strong bases, oxidants, and food-grade raw materials to prevent cross-contamination.

Packaging Specifications: Standard packaging is in 25kg cardboard drums (lined with polyethylene plastic bags, double-sealed). Small batches are packaged in 1kg/5kg vacuum-sealed aluminum foil bags to prevent moisture and facilitate easy handling.