chloromethyl 2-ethoxy-2-methylpropanoate

China [CN]

Structural Characteristics

The molecule is a propionate ester derivative with multiple substituents:

Parent structure: The carboxyl group of propionic acid forms an ester with a chloromethyl group (-CH₂Cl), forming a chloromethyl ester group (-OCH₂Cl);

Substituents: The 2-position of propionic acid is simultaneously linked to an ethoxy group (-OCH₂CH₃) and a methyl group (-CH₃), forming a quaternary carbon center (the 2-position carbon is linked to four groups: -OCH₂CH₃, -CH₃, -COOCH₂Cl, and -H).

This structure combines the stability of the ester group with the reactivity of the chloromethyl group, and the steric hindrance of the quaternary carbon, which influences its reaction selectivity.

Physical and Chemical Properties

Appearance: Typically a colorless to pale yellow liquid, with good clarity at higher purity.

Boiling Point: Estimated to be approximately 180-200°C (at atmospheric pressure, the specific value requires experimental determination). The boiling point decreases under reduced pressure, facilitating distillation and purification. Density: Approximately 1.08-1.10 g/cm³ (25°C, estimated).

Solubility: Sparingly soluble in water, readily soluble in organic solvents such as ethanol, ether, dichloromethane, and ethyl acetate, and highly compatible with most non-polar solvents.

Stability: Relatively stable at room temperature. Avoid contact with strong acids (which may catalyze ester hydrolysis), strong bases (which may induce ester hydrolysis or chloromethyl nucleophilic substitution), and strong oxidants. For long-term storage, keep sealed and protected from light.