2-AMino-5-cyano-4-phenylthiazole

China [CN]

Chemical Properties

Amino group reactions: The 2-position amino group can undergo acylation (reaction with acyl chlorides or anhydrides to form amides), alkylation (reaction with halogenated hydrocarbons to introduce alkyl groups), and diazotization (reaction with sodium nitrite under acidic conditions to form diazonium salts, which can further undergo coupling or substitution reactions).

Cyanide group reactions: The 5-position cyanide group can undergo hydrolysis (hydrolysis to carboxylic acids under acidic conditions, to amides under alkaline conditions), reduction (e.g., catalytic hydrogenation to form aminomethyl groups), and cycloaddition reactions (cyclization with compounds containing active hydrogens to form heterocycles).

Thiazole ring properties: The thiazole ring is aromatic and relatively stable. The phenyl group at the 4-position enhances the ring's rigidity through conjugation, and can serve as a ligand to form complexes with metal ions (e.g., transition metals).