2-amino-4-tert-butylthiazole-5-carbonitrile

China [CN]

Chemical Properties

Amine Reactivity: The amino group at position 2 undergoes typical amine reactions, such as acylation (reaction with acyl chlorides and anhydrides to form amides), alkylation (reaction with alkyl halides to introduce alkyl groups), and diazotization (reaction with sodium nitrite under acidic conditions to form diazonium salts, which can be further derivatized).

Cyanide Reactivity: The cyanide group at position 5 is highly reactive, undergoing hydrolysis (to form carboxylic acids or amides under acidic or alkaline conditions), reduction (to form aminomethyl groups), and cycloadditions, making it an important site for functional group transformations.

Thiazole Ring Stability: The thiazole ring is an aromatic heterocycle with good chemical stability, resistant to most organic reaction conditions. However, strong oxidative or hydrolytic conditions may lead to the destruction of the ring structure.

Steric Effects: The tert-butyl group at position 4 is relatively bulky, potentially affecting the molecule's reaction selectivity and interactions with other molecules (such as coordination and crystallization) through steric hindrance.