4-(chloromethyl)-1,3-thiazole

China [CN]

Physical and Chemical Properties: Typically a colorless to pale yellow liquid. Its boiling point is approximately 190-195°C, its relative density is approximately 1.32-1.36 (at 20°C), and its refractive index is approximately 1.540-1.550. It is readily soluble in organic solvents such as ethanol and dichloromethane, but insoluble in water.

Chemical Properties: The chloromethyl group in the molecule is highly reactive and can undergo nucleophilic substitution reactions, such as with nucleophiles such as alcohols and amines, to form corresponding ether and amine derivatives.

Uses: It is an important organic synthesis intermediate, widely used in the synthesis of pharmaceuticals, pesticides, and materials. For example, it can be used to synthesize thiazole intermediates with antibacterial and antiviral biological activities.

Safety: It is somewhat irritating and toxic. Harmful if swallowed, may cause respiratory irritation, and is also irritating to the skin and eyes. Handling requires protective equipment and a well-ventilated environment.