Thiazole-5-carboxylic acid

China [CN]

Physical and Chemical Properties

Appearance: Typically a white to pale yellow crystalline powder.

Melting Point: Approximately 208-210°C (decomposition).

Solubility: Slightly soluble in water, soluble in some organic solvents (such as ethanol and DMSO). Due to the presence of a carboxyl group (-COOH), its water solubility increases with increasing pH (forming carboxylates).

Chemical Properties: The molecule contains both a thiazole ring and a carboxyl group. The carboxyl group exhibits typical carboxylic acid chemical properties, such as esterification with alcohols and amidation with amines. The thiazole ring, on the other hand, possesses a certain degree of aromaticity and stability, making it suitable as a building block in organic synthesis.

Uses

It is primarily used as an organic synthesis intermediate for constructing complex molecules containing a thiazole ring. It has applications in medicinal chemistry, pesticide chemistry, and materials science. For example, through derivatization reactions of the carboxyl group (such as to form amides and esters), biologically active thiazole compounds can be synthesized. These compounds may possess pharmacological activities such as antibacterial, anti-inflammatory, and antiviral properties, or serve as active ingredients in pesticides.