Pharmaceutical Grade Estriol Hormone CAS 50-27-1 for Female Gonadal Dysfunction

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Pharmaceutical Grade Estriol Hormone CAS 50-27-1 for Female Gonadal Dysfunction
Posting date : Mar 19, 2018
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China [CN]
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Synonyms: TRIDESTRIN; (16-alpha,17-beta)-estra-1,3,5(10)-triene-3,16,17-triolCAS: 50-27-1MF: C18H24O3MW: 288.38Assay:≥98%Packing: Foil bagAppearance: White Crystalline PowderStandards: USP27Usage: A metabolite of Estradiol. An estrogenic metabolite considerably less potent than the hormone EstradiolCertification:    GMP, ISO 9001, USP, BPSuitable for:    Elderly, Adult
description:Estriol (E3), or oestriol, also known as 16α-hydroxyestradiol or as estra-1,3,5(10)-triene-3,16α,17β-triol, is a natural steroidal estrogen and one of the three main estrogens in the human body. Production of estriol by the ovaries is almost undetectable in non-pregnant women. However, during pregnancy, estriol is synthesized in very high amounts by the placenta and is by far the most produced estrogen in the body, although circulating levels are similar to those of other estrogens due to a relatively high rate of metabolism and excretion.Estriol belongs to natural hormone and is the metabolite of estradiol in vivo , anti estrogen steroids . It is mainly presented in the urine . Estrogen has a relative small activity with the oral activity being 6times as high as estrone but being weaker than estradiol with non-carcinogenic effects . After its administration , the in vivo estradiol levels did not change . Estriol has selective action on the vaginal and cervical canal but has no effect on the uterus and endometrium entity .
Estriol,Animal experiments have shown that estriol has a stronger effect on vaginal epithelial keratosis than estradiol , thus being able to promote vaginal epithelial hyperplasia , superficial cells keratosis ,mucosal angiogenesis and vaginal epithelial wound healing , but having a weak effect on the weight gain of mouse uterus At the same time , estriol can enhance the function of cervix cell , causing the cervix muscle fiber hyperplasia and increasing the cervical elasticity and softness .
In addition , estriol has feedback inhibition on the hypothalamus and pituitary but does not inhibitovulation while only having significant impact on the corpus luteum and therefore can be used as the auxiliary drug in the medium-term labor induction and artificial abortion and for the treatment of various kinds of menopathy . Estriol also has significant effect on the hematopoietic system and can reduce vascular permeability and fragility. Therefore , it can be used for the treatment of various kindsof hemorrhage . It also has effect of rapidly increasing the peripheral leukocytes and generally begins to take effect at 1 to 3 days after treatment but with a shorter duration of action and is effective in treatment the leukopenia induced by radiotherapy and chemotherapy . 
 Application :Estriol can be used for treating cervicitis and especially suitable for treating menopausalsyndromesenile vaginitis .Estriol can also be used as the adjuvant drug for middle-term labor induction and artificial abortion .Estriol can also be used for treating prostatic hypertrophy and prostate cancer .Estriol still has a rapid role in increasing the peripheral leukocytes. It generally takes effect at 1 to 3days afterthe treatment but with a short duration period . It also has efficacy in treating leukopeniacaused by chemotherapy or radiotherapyEstriol can be used for reducing the vascular permeability and fragility and can be used for thetreatment of various kinds of hemorrhage . It also has quick hemostasis effect on menorrhagia ,hysterectomy or tonsillectomy .
Packing:Discreet packing ways as your requirement, 100% go through.Storage:Store in cool and dry area and keep away from direct sunlight.
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1.We have stock so we can delivery quickly at the very day when receive the payment. 2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order. 3.High quality guarenteed, once any problem is found, the package would be reshipped for you4.Shipping by express (FedEx,UPS,DHL,EMS TNT HKEMS), by air.The most professional forwarder would be recommanded for you.5. Warm after-sale service for you 24/7. Any of your question would be solved for the first as soon as possible.Adhering to the principle of customer first conviction.we will provide the best and the most sincere services as possible as we can.   

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