White Crystalline Diazepam Powder Pharmaceutical Raw Materials CAS 439-14-5
China [CN]
| Diazapam Basic information |
| Product Name: | Diazapam |
| Synonyms: | 1-Methyl-5-phenyl-7-chloro-1,3-dihydro-2H-1,4-benzodiazepin-2-one;2H-1,4-Benzodiazepin-2-one,7-chloro-1,3-dihydro-1-methyl-5-phenyl-;2H-1,4-Benzodiazepine-2-one,7-chloro-1,3-dihydro-1-methyl-5-phenyl-;7-chloro-1,3-dihydro-1-methyl-5-phenyl-2h-4-benzodiazepin-2-one;7-Chloro-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepine;7-Chloro-1-methyl-5-3H-1,4-benzodiazepin-2(1H)-one;7-Chloro-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one;7-Chloro-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one |
| CAS: | 439-14-5 |
| MF: | C16H13ClN2O |
| MW: | 284.74 |
| EINECS: | 207-122-5 |
| Product Categories: | Miscellaneous Biochemicals;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Benzodiazepin Analoga StructureAlphabetic;DIA - DICForensic and Veterinary Standards;Chemical Structure;D;Drugs of Abuse;Drugs&Metabolites;Solutions |
| Mol File: | 439-14-5.mol |
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| Diazapam Chemical Properties |
| Melting point | 131.5-134.5°C |
| Fp | 11 °C |
| storage temp. | 2-8°C |
| solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.6 mg/mL |
| Stability: | Stable. Light-sensitive. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 439-14-5(CAS DataBase Reference) |
| NIST Chemistry Reference | 2H-1,4-benzodiazepin-2-one, 7-chloro-1,3-dihydro-1-methyl-5-phenyl-(439-14-5) |
| EPA Substance Registry System | 2H-1,4-Benzodiazepin- 2-one, 7-chloro-1,3-dihydro-1-methyl- 5-phenyl-(439-14-5) |
| Safety Information |
| Hazard Codes | Xn,T,F,Xi |
| Risk Statements | 21/22-39/23/24/25-23/24/25-11-36/37/38 |
| Safety Statements | 36/37-45-36-26-16-7 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 2 |
| RTECS | DF1575000 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Hazardous Substances Data | 439-14-5(Hazardous Substances Data) |
| MSDS Information |
| Provider | Language |
|---|---|
| 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one | English |
| SigmaAldrich | English |
| Diazapam Usage And Synthesis |
| Chemical Properties | Light Yellow Crystalline Solid |
| Usage | Anxiolytic; muscle relaxant (skeletal); anticonvulsant. Controlled substance (depressant). |
| Usage | Diazepam is an anxiolytic; muscle relaxant (skeletal); anticonvulsant. Diazepam is a controlled substance (depressant). |
| Usage | Anxiolitic; muscle relaxant (skeletal); anticonvulsant. Controlled substance (depressant) |
| General Description | Off-white to yellow crystalline powder. Practically odorless. Tasteless at first with a bitter aftertaste. |
| Air & Water Reactions | Hydrolysis occurs in aqueous solutions with a maximum stability around pH 5. . Insoluble in water. |
| Fire Hazard | Flash point data for Diazapam are not available; however, Diazapam is probably combustible. |
| Biological Activity | Ligand at the GABA A receptor benzodiazepine modulatory site. Anxiolytic, anticonvulsant and sedative/hypnotic agent. |
| Diazapam Preparation Products And Raw materials |
| Raw materials | Hydrochloric acid-->Acetone-->Benzene-->Dimethyl sulfate-->Hexamethylenetetramine-->Chloroacetyl chloride-->2-Amino-5-chlorobenzophenone |
| Preparation Products | diazepam-polyhydroxybutyrate microspheres |
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