Lopsitinib (TPX-0005) is a fourth-generation ALK inhibitor developed by TPTherapeutics, founded by Dr. Cui Jingrong. It is a broad-spectrum ALK, ROS1 and TRK inhibitor, mainly targeting multiple acqui…
The second-generation ALK inhibitor enxatinib (X-396) is comprehensively superior to the first-generation crizotinib. Global multi-center Phase 3 clinical trials began in June 2016, and the approval f…
Cabozantinib malate is a small molecule C-Met modulator. Cabozantinib malate can be used as an effective multi-target inhibitor of VEGFR2, Met, FLT3, Tie2, Kit and Ret. The IC50 values of cabozantinib…
Crizotinib (XalkoriR), chemically known as 3-[(R)-1-(2, 6-dichloro-3-fluorophenyl) ethoxy]-5-[1-(piperidin-4-yl) -1H-pyrazole-4-yl Chemicalbook] pyridine-2-amine, is a white to light yellow powder in …
Camatinib (INC280; INCB28060 is a potent, oral, selective, ATP-competitive c-Met kinase inhibitor (IC5Chemicalbook0=0.13nM). Camatinib can effectively inhibit the proliferation and migration of C-MET-…
Lorlatinib (PF-06463922) is an ALK inhibitor modified from Crizotinib by Pfizer of the United States. This drug entered clinical trials in 2014 for the treatment of lung cancer as described in Chemica…
Niraparib toluenesulfonic acid monohydrate is the toluenesulfonic acid salt and hydrated form of niraparib. It is also a selective inhibitor of PARP1/2 (IC50 = 3.8 nM and 2.1 nM) and has been approved…
Sorafenib (trade name Dorgime) is a new drug of molecular targeted therapy. It is an oral multi-target and multi-kinase inhibitor that can target serine/threonine kinases and receptor tyrosine kinases…
Lenalidomide is an immunomodulatory drug. This drug has multiple mechanisms of action. In vitro studies have shown that lenalidomide has three main functions :1) direct anti-tumor effect 2) inhibition…
Breast cancer and ovarian cancer are serious public health problems that seriously threaten women. However, in recent years, the growth rate of breast cancer incidence in China has been 1-2 percentage…
A white or grayish-white non-hygroscopic crystalline solid with a melting point of 195-196℃, it is readily soluble in DMSO and acetonitrile, slightly soluble in anhydrous ethanol, and insoluble in wat…
Abiraterone acetate was initially developed through a collaboration between Cancer Research UK and BTG. Later, the global development rights and marketing rights were transferred to Cougar Biopharmace…
Axitinib (axitinib) is a multi-target small molecule inhibitor, with its main targets being VEGFR, Kit, PDGFR, and RET. The currently approved indication for marketing is the second-line treatment of …
Pazopanib is a novel oral angiogenesis inhibitor developed by GlaxoSmithKline that can interfere with the formation of new blood vessels necessary for the survival and growth of stubborn tumors. It ta…
Ettelavir belongs to 4-quinolone-3-glyoxyacid antiretroviral drugs. It is an HIV integrase inhibitor that can inhibit the transfer of viral DNA strands by HIV integrase, thereby affecting viral replic…
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