Zanubrutinib is designed to minimize the inhibition of non-targeted kinases while achieving the maximum drug exposure. In kinase inhibition and cell-based experiments, zanubrutinib demonstrated superi…
Fantorimod is a sphingosine -L-phosphate (S1PR) receptor modulator. After phosphorylation in vivo, it binds to the s1P receptor on the surface of lymphocytes, alters the migration of lymphocytes, prom…
Everolimus is a derivative of sirolimus, also known as 40-O-(2-hydroxyethyl) -rapamycin or 40-O-(2-hydroxyethyl) -sirolimus. It belongs to the kinase class of drugs that interfere with cell communicat…
Rituximab is a chimeric murine - human monoclonal antibody specifically targeting B cells. It recognizes and specifically binds to CD20, which is only expressed on the surface of pre-B cells and matur…
Pertuzumab (also known as 2C4, trade name Perjeta) is a monoclonal antibody. It is the first monoclonal antibody to be called "HEChemicalbookR dimerization inhibitor". By binding to HER2, it…
As an anti-angiogenic drug, it targets the IgG1 monoclonal antibody that acts on vascular endothelial growth factor (VEGF), competitively inhibiting the binding of vascular endothelial cell surface re…
Trastuzumab is used to treat breast cancer. It is effective for tumors that overexpress HER2/neu proteins. As part of the chemotherapy regimen for adjuvant treatment of lymph node-positive, HER2/neu p…
Osimertinib mesylate (AZD9291) is the mesylate form of osimertinib and is an oral third-generation epidermal growth factor receptor (EGFR) tyrosine kinase (TKI) inhibitor.
Calcium levofolinate is the calcium salt of levofolinate. Levofolinate is an isomer of 5-formyltetrahydrofolate (i.e., folinate). Another form of folinate is the dl body, that is, DL-chemicalbookLV. I…
alectinib (CH5424802) is an effective ALK inhibitor with an IC50 of 1.9nM. It is sensitive to the L1Chemicalbook196M mutant and has higher selectivity for ALK than PF-02341066, NLP-TAE684 and PHA-E429…
It is a small molecule gonadotropin-releasing hormone (GnRH) receptor antagonist and has the potential to be used in indications such as uterine fibroids, endometriosis, and prostate cancer.
Ruxolitinib phosphate is an effective JAK1/2 inhibitor with IC50 values of 3.3 nM/2.8 nM respectively, and its selectivity is 130 times higher than that of JAK3.
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