Wuhan Yuanqi pharmchem Co.,Ltd.

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Wuhan Yuanqi pharmchem Co.,Ltd.
TEL : 86-027-88080696 / FAX : 86-027-88082096 / Mobile :
Sanjiang port Hubei Ezhou China [CN]
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Business Type
Manufacturer
Product
6-Bromoandrostenedione
Posting date : Dec 17, 2008
Membership
Free Member Scince Aug 08, 2008
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Quick Detail
Place of Origin
China [CN]
HS-CODE
30-
Package & Delivery Lead Time
Detailed Description
Product Name:6-Bromoandrostenedione CAS Number:38632-00-7 A selective inhibitor of aromatase (estrogen synthetase) would be a useful pharmacological tool with potential therapeutic application. We have found that 6 alpha-bromoandrostenedione (6 alpha-BrA) is a competitive inhibitor of human ntal aromatase with respect to androstenedione, with an apparent Ki of 3.4 nM, while 6 beta-BrA is a mechanism-based irreversible inhibitor with an apparent Ki of 0.8 microM and a kinact of 0.025 min-1. Aromatase activity was measured by tritium release into water from the 1 beta position of [1(-3)H,4(-14)C]androstenedione in reaction mixtures containing NADPH and the aromatase.

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