DES (1-3) IGF-1, also named IGF-1 Des (1-3), IGF-1 Des 1-3, is another type of IGF-1 that occurs naturally and synthetically. It is missing the first three amino acids from the IGF-1 amino acid chain. It is composed of 67 amino acids and has a molecular weight of 7360.5 Da. The missing amino acids make it less effective at binding to IGF proteins, mostly because of the glutamate amino acid missing from position 3. The structural difference makes it 10x more potent than IGF-1.
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