Optogenetics is a booming multidisciplinary bioengineering technology. It has the characteristic of high spatial-temporal resolution and cell-type specific. It overcomes the disadvantages of traditional methods of the activity control for the cell and organism, and also provides a revolutionary method for the research of neuroscience. The research fields include fundamental research of neural circuit, study and memory research, habituation research, dyskinesia, sleep disorders, parkinsonism, depressive disorder, anxiety disorder etc., and many classic laboratory animal germ line(drosophila melanogaster, nemathelminth, mice, Marmoset, and machin etc.).
Neuroscience is the scientific study of the nervous system. It is currently an interdisciplinary science that collaborates with other fields such as chemistry, computer science, engineering, linguistics, mathematics, medicine, genetics, and allied disciplines including philosophy, physics, and psychology. It also exerts influence on other fields, such as neuroeducation and neurolaw. The scope of neuroscience has broadened to include different approaches used to study the molecular, cellular, developmental, structural, functional, evolutionary, computational, and medical aspects of the nervous system.
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Opsin
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channelrhodopins-2
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halrohodopsin
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abbreviation
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ChR2
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NpHR
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activation method
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Na+、Ca+、K+
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Cl-
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sensitive wavelength
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~473nm
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~589nm
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Changchun New Industries (CNI) founded in 1996, is a leading manufacturer of solid-state and diode laser systems. CNI laser features with high performance, nice reliability, and specifically designed for OEM, scientific, industrial and instrumentation use. In addition, CNI lasers are ISO-9001, FDA, CE, RoHS and JQA certified. CNI can provide different lasers for Optogenetics with free space and pigtailed versions. Also the accessories used for Optogenetics are available for a total solution from customer.
Research achievements of CNI laser for Optogenetics from customers
(1) Optogenetic stimulation of a hippocampal engram activates fear memory recall (Nature, 484(7394): 381–385. doi:10.1038/nature11028) (CNI-473nm)
(2) Ultrahigh accuracy imaging modality for super-localization microscopy(Nature Methods, VOL.10,2013,335) (CNI-635nm and 488nm)
(3) Remote Optogenetic Activation and Sensitization of Pain Pathways in Freely Moving Mice(The Journal of Neuroscience, 2013•33(47):18631–18640) (CNI-589nm)
(4) Optogenetic Evidence That Pallidal Projections, Not Nigral Projections, from the Nucleus Accumbens Core Are Necessaryfor Reinstating Cocaine Seeking(The Journal of Neuroscience, 2013•33(34):13654–13662) (CNI-561nm)
(5) Control of a specific motor program by a small brain area in zebrafish(Front Neural Circuits, 2013; 7: 67) (CNI-405nm and 457nm)
(6) Fatal Neurological Respiratory Insufficiency Is Common Among Viral Encephalitides (Oxford Journals, 2013:208) (CNI-470nm)
(7) Temperature-dependent Activation of Neurons by Continuous Near-infrared Laser (Cell Biochemistry and Biophysics,vol.53, 33-42,2009)(CNI-1064nm)
(8) Distal connectivity causes summation and division across mouse visual cortex (Nature Neuroscience, 2014,Volume:17,Pages:30–32) (CNI-473nm)
(9) Remote activation of biomolecules in deep tissues using near-infrared-to-UV upconversion nanotransducers(PNAS,2012,109(22),8483-8488) (CNI-980nm)
(10) Viral Vector-Based Techniques for Optogenetic Modulation In Vivo(Viral Vector Approaches in Neurobiology and Brain Diseases Neuromethods, Volume 82, 2014, pp 289-310) (CNI-447nm)
(11) Optogenetic Inhibition of Dorsal Medial Prefrontal Cortex Attenuates Stress-Induced Reinstatement of Palatable Food Seeking in Female Rats (The Journal of Neuroscience, 2013, 33(1):214–226) (CNI-593.5nm)
(12) Glutamatergic Signaling by Mesolimbic Dopamine Neurons in the Nucleus Accumbens (The Journal of Neuroscience, 2010, 30(20):7105-7110) (CNI-453nm)
(13) Firing of Hippocampal Neurogliaform Cells Induces Suppression of Synaptic Inhibition (The Journal of Neuroscience, 2014•34(4):1280–1292) (CNI-532nm)
(14) Intrinsic Electrophysiology of Mouse Corticospinal Neurons: a Class-Specific Triad of Spike-Related Properties (Oxford Journals, Volume 23,Issue 8,1965-1977) (CNI-473nm)
(15) Au–PLA nanocomposites for photothermally controlled drug delivery (J. Mater. Chem. B, 2014,2, 409-417)(CNI-808nm)
(16) Synthesis of magnetic, fluorescent and mesoporous core-shell-structured nanoparticles for imaging, targeting and photodynamic therapy (J. Mater. Chem., 2011,21, 11244-11252)(CNI-660nm)
(17) Asphaltene Adsorption onto an Iron Surface: Combined Near-Infrared (NIR), Raman, and AFM Study of the Kinetics, Thermodynamics and Layer Structure (Energy Fuels,2011,25(1), pp 189–196)(CNI-633nm)
(18) The electrophysiological properties of voltage-gated potassium channels on cultivated porcine retinal ganglion cells irradiated with continuous near-infrared laser (Chinese journal of ophthalmology 02/2012; 48(2):153-8).(CNI-845nm)
(19) High-resolution simultaneous voltage and Ca2+imaging (J Physiol February 1, 2011.589(3)489-494)(CNI-543nm)
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Jackie Wei
Changchun New Industries Optoelectronics Tech.Co.,Ltd.
Address: No.888 Jinhu Road High-tech Zone, Changchun 130103, P.R.China
Tel/Fax: 0086-431-85603799 / 87020258
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Website: http://www.cnilaser.net
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